Information

Cavalieri’s main interest is the role of microorganisms in self sustainability of fundamental ecosystem services (here), with a focus on  the evolution of regulatory networks shaping host microbe-interactions, in health and disease.

His research started from the study of evolutionary genomics ofSaccharomyces cerevisiae, investigating the molecular determinants of the interaction of diet microorganisms and immune system and the transition from commensalism to pathogenicity.

Currently his main scientific focus is the ecology of the fungal “holobiome”, the complex network of symbiotic interactions linking fungi and the host. In this perspective Cavalieri’s team has mastered the application of bioinformatics, metagenomics, and immunobiology, to the analysis of community structure, gene content, and function of complex microbial communities.

The major outcomes of his research are: The elucidation of the ecological cycle and sexual habits of the ascomycete S.cerevisiae and its wild sanctuaries, including social insects. The understanding of the role of S.cerevisiae in the mechanism of trained immunity. The discovery of dietary miRNAs as immunomodulators in a nutrigenomics perspective.

Duccio Cavalieri is currently professor of Microbiology at the University of Florence, previously he was Harvard Fellow and Group Leader at the Center for Genomics research at Harvard (1999-2005), Group Leader and Assistant Professor at the Department of Pharmacology at the University of Florence (2004-2010) and Computational Biology Department Director and Group Leader at the Fondazione Edmund Mach (2010-2015).

 

Download Duccio Cavalieri’s CV here

 

See Duccio Cavalieri publications in Pubmed here

 

Recent Highlghts.

  1. The Paper I Stefanini , Dapporto L, Berna L, Polsinelli M., Turillazzi S , Cavalieri D. Social wasps are a Saccharomyces mating nest. Proc Natl Acad Sci US A. 2016 Feb 23;113(8):2247-51. doi: 10.1073/pnas.1516453113. Epub 2016. The publication (which can be found here), has been higlighted with an interview to Duccio Cavalieri in Science, The Scientist, il Corriere della Sera, Science Videos and 40 other web sites.

  2. Cavalieri D, Rizzetto L, Tocci N., Rivero D., Asquini E., Si- Ammour A., Bonechi E., Ballerini C., Viola R., Plant microRNAs as novel immunomodulatory agents. Sci Rep., | 6:25761 | DOI: 10.1038/srep25761, 2016 May 11. The publication can be found here. See the UNIFI press release here 

      Comunicato_Stampa_miRNA_Unifi.pdf (234.5 KiB, 151 hits)



  3. Rizzetto L, Ifrim DC, Moretti S, Tocci N, Cheng SC, Quintin J, Renga G, Oikonomou V, De Filippo C, Weil T, Blok BA, Lenucci MS, Santos MA, Romani L, Netea MG, Cavalieri D. Fungal chitin induces trained immunity in human monocytes during cross-talk of the host with Saccharomyces cerevisiae. J Biol Chem. 2016 Feb 17. pii: jbc.M115.699645. The publication can be found here

  4. Convenor and Organizer of ICGYMB 2015, 27th International Conference on Yeast Genetics and Molecular Biology, Levico terme 6th-12th September 2015, See here.

  5. Organizer speaker and award winner, Symbiomes: Systems Biology of Host Microbe Interactions, ESF-EMBO, 5-10 June 2015, Pultisk Poland, See here.

 

Other Selected Publications

  1. Rivero D, Berná L, Stefanini I, Baruffini E, Bergerat A, Csikász-Nagy A, De Filippo C, Cavalieri D. Hsp12p and PAU genes are involved in ecological interactions between natural yeast strains. Environ Microbiol. 2015 Jul 30. doi: 10.1111/1462-2920.12950. The publication can be found here

  2. Rizzetto L, De Filippo C, Cavalieri D. Richness and diversity of mammalian fungal communities shape innate and adaptive immunity in health and disease. Eur J Immunol. 2014 Sep 25. The publication can be found here

  3. The paper ” I Stefanini , Dapporto L, Legras JL , Calabretta A, Di Paola M, De Filippo C , Viola R , P Kids , Polsinelli M, Turillazzi S , Cavalieri D. Role of social wasps in Saccharomyces cerevisiae ecology and evolution. Proc Natl Acad Sci US A. 2012 Aug 14; 109 (33) : 13398-403″ (The publication can be found here), cited won the Magni Award as best publication from an Italian Scientist in 2013, and has been broadcasted on National Public Radio NPR (here),Wine Spectator Online (here), the New York Times, of the 06/08/2012 (here).


  4. Ramazzotti M, Berná L, Stefanini I, Cavalieri D. A computational pipeline to discover highly phylogenetically informative genes in sequenced genomes: application to Saccharomyces cerevisiae natural strains. Nucleic Acids Res. 2012 May;40(9):3834-48. The publication can be found here

  5. The work “Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa” (De Filippo C, Cavalieri D, et al., PNAS . 2010 107 (33) : 14691-6. The publication can be found here), broadcasted on The Economist and the major newspapers and TVs, had a huge impact on both on the scientific community and on society in general. The article is the second most cited articles in PNAS since 2010 (over 1170 citations ) and has been invited for presentation at the TEDx Roncade on Biodiversity 2014, See here.

 

  1. http://www.informasalus.it/it/articoli/sistema-immunitario-piante.php
  2. http://www.sciencemag.org/news/2016/01/brewer-s-yeasts-mate-inside-guts-hibernating-wasps
  3. http://www.the-scientist.com/?articles.view/articleNo/45106/title/Yeasts-Mate-in-Wasp-Guts/,
  4. http://news.yahoo.com/discovering-wild-side-yeast-174931321.html,
  5. http://www.livescience.com/53404-brewers-yeast-has-sex-in-wasp-guts.html,
  6. http://www.agenciasinc.es/Multimedia/Fotografias/Distintos-tipos-de-levaduras-se-cruzan-en-las-tripas-de-las-avispas.
  7. http://polit.ru/news/2016/01/19/ps_yeasts/
  8. http://www.takepart.com/article/2016/01/19/discovering-wild-side-yeast
  9. http://www.focus.it/ambiente/animali/vino-le-vespe-lo-fanno-meglio
  10. http://trentinocorrierealpi.gelocal.it/trento/cronaca/2016/01/20/news/la-scoperta-vespe-fondamentali-per-la-fermentazione-del-vino-1.12809908
  11. http://www.greenreport.it/news/aree-protette-e-biodiversita/cosa-servono-vespe-vino/
  12. http://ecologia.guidone.it/2016/01/20/se-muoiono-le-vespe-diciamo-addio-al-vino/
  13. http://www.meteoweb.eu/2016/01/vino-le-vespe-possono-aiutarne-la-fermentazione/619866/
  14. http://www.gonews.it/2016/01/20/firenze-vino-le-vespe-fondamentali-per-la-fermentazione-studio-delluniversita/
  15. http://www.firenzetoday.it/green/life/vino-vespe-fare.html
  16. http://www.laperfettaletizia.com/2016/01/a-cosa-servono-le-vespe-fare-il-vino.html
  17. http://www.adnkronos.com/fatti/cronaca/2016/01/20/vespe-fermentano-meglio-vino-dice-scienza_2wOzpfewUUsX7PkeocFAAJ.html
  18. http://www.ansa.it/canale_terraegusto/notizie/vino/2016/01/20/vino-vespe-fondamentali-per-fermentazione_1edb4110-19e5-4ebe-a0b7-14c440242a21.html
  19. http://www.examiner.com/article/study-proves-no-wine-or-beer-possible-without-wasp-poop
  20. http://phys.org/news/2016-01-brewer-yeast-hybridizes-wasp-gut.html
  21. http://www.ibe.upf-csic.es/
  22. http://ilfoglietto.it/il-foglietto/4402-la-funzione-delle-vespe-nella-fermentazione-naturale-dei-vini.html
  23. http://www.farmacia.it/index.php/news/articolo/23/14467
  24. http://www.italiaambiente.it/it/cibo2/15-mangiare-sano/52-vino-vespe
  25. http://www.9colonne.it/108273/vino-sono-le-vespe-br-a-farlo-meglio#.VqDq0UvFlg0
  26. http://www.corriere.it/notizie-ultima-ora/Scienza_e_salute/Vespe-fondamentali-fermentazione-vino/20-01-2016/1-A_022096971.shtml
  27. http://www.improntaunika.it/2016/01/vino-le-vespe-fondamentali-per-la-fermentazione-e-garantiscono-la-biodiversita/
  28. http://www.news24web.it/304002016/vino-le-vespe-ne-favoriscono-la-fermentazione/
  29. http://www.centritaliaonline.com/1021/scienza-scoperto-legame-tra-le-vespe-e-la-fermentazione-del-vino/
  30. http://www.ansa.it/canale_terraegusto/notizie/vino/2016/01/20/vino-vespe-fondamentali-per-fermentazione_1edb4110-19e5-4ebe-a0b7-14c440242a21.html
  31. https://www.nkj.ru/news/28003/
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  33. http://www.thestar.com/life/2015/08/07/bugs-help-create-tasty-new-beers-scientists-discover.html
  34. http://www.ilcaffevitruviano.it/food-and-love/fluid/item/2590-vino-la-fermentazione-grazie-alle-vespe.html
  35. http://sciencevideos.org/duccio-cavalieri-social-wasps-are-a-saccharomyces-mating-nest/
  36. http://www.yeastgenome.org/wintering-in-a-wasps-gut
  37. http://www.yeastgenome.org/of-medieval-market-townes-and-wasp-guts
  38. http://www.stuttgarter-zeitung.de/inhalt.gaerung-wein-und-bierhefe-aus-dem-wespendarm.29b0ef01-88c0-4d63-b4dd-e12031ab8447.html
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  41. https://www.researchitaly.it/en/understanding/press-media/news/le-vespe-fanno-il-vino-buono-una-ricerca-italiana/
  42. https://www.youtube.com/watch?v=fpytstwzIHc
  43. https://www.youtube.com/watch?v=dEy18XH4lPY
  44. https://www.youtube.com/watch?v=T8K32wmTXQg
  45. http://www.gonews.it/2015/03/12/giornata-della-scienza-liniziativa-per-le-scuole-superiori-sulla-ricerca-sulle-staminali/
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  47. http://www.thestar.com/life/2015/08/07/bugs-help-create-tasty-new-beers-scientists-discover.html
  48. http://www.npr.org/blogs/thesalt/2012/08/02/157606554/thank-the-simple-wasp-for-that-complex-glass-of-wine
  49. http://www.nytimes.com/2012/08/07/science/dont-swat-that-bug-it-may-be-working-on-next-years-vintage.html?_r=0
  50. http://www.winespectator.com/webfeature/show/id/47188
  51. http://www.youtube.com/watch?v=oGTJErd4rbw
  52. https://www.bspghan.org.uk/education
  53. http://en.wikipedia.org/wiki/Gut_flora
  54. http://www.economist.com/node/16740669
  55. http://news.sciencemag.org/2010/08/western-diet-tied-intestinal-disease-and-allergies
  56. http://edition.cnn.com/2010/HEALTH/08/03/food.allergies.er.gut
  57. http://www.welt.de/welt_print/wissen/article8788428/Bohnen-und-Linsen-schuetzen-vor-Allergien.html